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Adjuvant Hepatic Arterial Infusion Pump Chemotherapy After Resection of Colorectal Liver Metastases: Results of a Safety and Feasibility Study in The Netherlands

Florian E. Buisman MD, Dirk J. Grünhagen MD, PhD, Marjolein Y. V. Homs MD, PhD, Cecile Grootscholten MD, PhD, Wills F. Filipe MD, Nancy E. Kemeny MD, Andrea Cercek MD, Micheal I. D’Angelica MD, Maarten L. Donswijk MD, Leni van Doorn NP, Jasper Emmering MD, PhD, William R. Jarnagin MD, T. Peter Kingham MD, Elisabeth G. Klompenhouwer MD, PhD, Niels F. M. Kok MD, PhD, Maria C. Kuiper NP, Adriaan Moel
Hepatobiliary Tumors
Volume 26, Issue 13 / December , 2019

Abstract

Background

The 10-year overall survival with adjuvant hepatic arterial infusion pump (HAIP) chemotherapy after resection of colorectal liver metastases (CRLMs) was 61% in clinical trials from Memorial Sloan Kettering Cancer Center. A pilot study was performed to evaluate the safety and feasibility of adjuvant HAIP chemotherapy in patients with resectable CRLMs.

Study Design

A phase II study was performed in two centers in The Netherlands. Patients with resectable CRLM without extrahepatic disease were eligible. All patients underwent complete resection and/or ablation of CRLMs and pump implantation. Safety was determined by the 90-day HAIP-related postoperative complications from the day of pump placement (Clavien–Dindo classification, grade III or higher) and feasibility by the successful administration of the first cycle of HAIP chemotherapy.

Results

A total of 20 patients, with a median age of 57 years (interquartile range [IQR] 51–64) were included. Grade III or higher HAIP-related postoperative complications were found in two patients (10%), both of whom had a reoperation (without laparotomy) to replace a pump with a slow flow rate or to reposition a flipped pump. No arterial bleeding, arterial dissection, arterial thrombosis, extrahepatic perfusion, pump pocket hematoma, or pump pocket infections were found within 90 days after surgery. After a median of 43 days (IQR 29–52) following surgery, all patients received the first dose of HAIP chemotherapy, which was completed uneventfully in all patients.

Conclusion

Pump implantation is safe, and administration of HAIP chemotherapy is feasible, in patients with resectable CRLMs, after training of a dedicated multidisciplinary team.

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