Ki-67 and Bcl-2 Antigen Expression in Adenomatous Colorectal Polyps from Women with Breast Cancer

Edílson Carvalho de Sousa-Júnior MD, Airlane Pereira Alencar PhD, Benedito Borges da Silva MD, PhD
Breast Oncology
Volume 17, Issue 9 / September , 2010

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Abstract

Background

The aim of this study was to evaluate Ki-67 and Bcl-2 antigen expression in colorectal polyps from women with breast cancer.

Methods

A randomized, controlled study was carried out in 35 women, either with or without breast cancer, who had adenomatous colorectal polyps. The patients were divided into two groups: group A (without breast cancer; control group; n = 17) and group B (with breast cancer; study group; n = 18). Immunohistochemistry was performed on the colorectal polyps to evaluate Ki-67 and Bcl-2 antigen expression. Student’s t-test and the χ² test were used for the statistical analysis of Ki-67 and Bcl-2 expression, respectively. Statistical significance was established as P < 0.05.

Results

The mean percentage of Ki-67-stained nuclei in groups A and B was 36.25 ± 2.31 and 59.44 ± 3.34 (± SEM), respectively (P < 0.0001), while the percentage of cases with cells expressing Bcl-2 in groups A and B was 23.5 and 77.8%, respectively (P < 0.001).

Conclusions

In the present study, there was greater proliferative activity and greater expression of the antiapoptotic protein Bcl-2 in the colorectal polyps of women with breast cancer.

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